Pixyl.Neuro.MS integrates into the routine workflow, to extract pertinent information on the size and location of Multiple Sclerosis (MS)-specific lesions, aimed at supporting the diagnosis and monitoring of patients. In case of multiple visits, the longitudinal analysis also provides data on the evolution of the lesions, and therefore on the activity of the disease with respect to diagnostic criteria. The software outputs both a quantitative report on lesion location, volume and evolution, as well as annotated MRI images with lesions labeled according to their evolution.